منابع مشابه
Apoptosis leaves its mark on chromatin
n mammalian cells the work of the cell cycle is divided between two workhorses: Cdk2/cyclin E for S phase and Cdk1/cyclin B for mitosis. show that this apparent specificity is achieved by limiting access to substrates. By denying entrance to the nucleus, cells prevent Cdk1–cyclin B from jumpstarting S phase at inopportune times. In frog egg extracts, S phase is induced in nuclei by Cdk2–cyclin ...
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Lipid storage diseases are debilitating inherited metabolic disorders that stem from the absence of specific lysosomal enzymes that degrade selected lipids. Most characteristically, these disorders affect the nervous and the reticulo-endothelial systems, with massive organomegaly resulting from the presence of engorged, lipid-laden macrophages. In this issue of the JCI, Yildiz et al. describe t...
متن کاملHistory Leaves Its Mark on Soil Bacterial Diversity
Dispersal is closely tied to the origin and maintenance of microbial diversity. With its focus on a narrow group of soil bacteria, recent work by Andam and colleagues on Streptomyces has provided perhaps the strongest support so far that some bacterial diversity in soils can be attributed to regional endemism (C. P. Andam et al., mBio 7:e02200-15, 2016, http://dx.doi.org/10.1128/mBio.02200-15)....
متن کاملNuclear Position Leaves Its Mark on Replication Timing
The multiple replication origins of eukaryotic chromosomes are programmed to replicate at specific times throughout S phase of the cell cycle. The functional significance of this program is not understood, but, in general, transcriptionally active chromatin replicates early in S phase, whereas hypoacetylated, transcriptionally inactive chromatin replicates later. During metazoan development, mu...
متن کاملPolyadenylation and degradation of human mitochondrial RNA: the prokaryotic past leaves its mark.
RNA polyadenylation serves a purpose in bacteria and organelles opposite from the role it plays in nuclear systems. The majority of nucleus-encoded transcripts are characterized by stable poly(A) tails at their mature 3' ends, which are essential for stabilization and translation initiation. In contrast, in bacteria, chloroplasts, and plant mitochondria, polyadenylation is a transient feature w...
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ژورنال
عنوان ژورنال: III-Vs Review
سال: 1999
ISSN: 0961-1290
DOI: 10.1016/s0961-1290(00)80025-3